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The third binding site is the Arrestin box, which binds (L/I) 2 GxL motifs from a splice variant of Arrestin 2 19

CpG dinucleotides are unevenly distributed in mankind genomes, predominantly clustering in CpG islands (CGIs), which are short, interspersed DNA sequences that deviate significantly from the typical genomic pattern and are characterized by their abundance of unmethylated CpG dinucleotides

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Mitochondrial abnormalities in patients with primary open-angle glaucoma