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Activated Nrf2 translocates to the nucleus, where it triggers the expression of antioxidants such as glutathione redox system components, enzymes that regulate iron metabolism, and other pertinent molecules, which can inhibit ferroptosis

[60] reported decreases in MT mRNA levels in response to high glucose concentration in -cells in a mice model

Blum MA, Hayashi Y, Xiao L, Suzuki A, Sabloff B, Maru DM, Taketa T, Welsh J, Lin SH, Lee JH, Bhutani MS, Weston B, Hofstetter WL, Swisher S , Ajani JA

strongly suggest that vesicular release from astrocytes plays a minor role, as the Ca +2 -mediated release of L-glu was still present in astrocytes derived from dominant-negative SNARE mice (Wang et al., 2013) where vesicular release can be blocked by doxycycline withdrawal (Pascual et al., 2005)