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These compounds have shown promise in preclinical models and are currently undergoing evaluation in clinical trials to assess safety, effectiveness, and long-term benefits ( Key Senolytic Compounds, Their Mode of Action, and Evidence from Preclinical and Clinical Trials Challenges in Senolytic Therapy Despite the promising potential of senolytic therapy in combating aging and age-related diseases, several challenges must be addressed before widespread clinical application

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Studies using synthetic DSIP should account for which isomeric form was used when comparing results across papers

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However, as with any topically applied active ingredient, reactions can occur, particularly in individuals with sensitive skin or pre-existing scalp conditions such as seborrhoeic dermatitis or psoriasis