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doi: 10.1016/j.sleep.2023.05.006 117

Minimizes the Look of Wrinkles and Fine Lines

doi: 10.1126/scitranslmed.aay3069 40 DeaneR.SagareA.HammK.ParisiM.LaneS.FinnM

In cervical cancer (HeLa) cells, apigenin induce apoptosis via two distinct pathways: one involves down-regulating Bcl-2 protein expression, while the other activates p53 to varying degrees, leading to the induction of p21, fatty acid synthase (Fas) expression and ultimately apoptosis [80]

In the setting of CIRS, sustained MMP-9 elevation drives endothelial permeability, immune cell infiltration, and the release of sequestered inflammatory mediators such as TNF- and IL-1, amplifying systemic immune activation