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Gastroenterology (2017) 153(2):4209

As previously demonstrated, the in vivo administration of N-acetylcysteine attenuates acute TNBS-induced colitis in rats through increased mucosal GSH levels, reducing the extent of intestinal mucosal injury and TNBS-induced ROS overgeneration (127)

To this end, the development of new therapies, ideally targeting synovitis and inflammatory-related bone erosion in joints, as well as regulating those inflammation-independent factors that can also interfere with bone homeostasis in RA, such as the general RANKL signaling pathway, would be promising for remodeling bone homeostasis in RA

Zhang X, Piano I, Messina A, DAntongiovanni V, Cr F, Provenzano G, et al

These findings underscore the multiple mechanisms of action and clinical application prospects of B vitamins in managing LLD