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Antioxidants can slow the progression of these disorders by modulating microglial function and activity

This results in activated T cells & B cells that produce an anti-citrulline inflammatory response that affects the joints, resulting in swelling and degradation of both cartilage and bone (Schur & Firestein, 2012) as illustrated in Figures 3, 4 & 5

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If electrons from ascorbate fully reduce O 2 to water (2AscH + O 2 + 4H + 2H 2 O + 2DHA), then 0.0005 M of ascorbate will be lost to this oxidation, or (0.0005 M/1

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