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R(+)-Pulegone administered orally to rats by gavage at a dose of 400 mg/kg bw per day for up to 5 days decreased liver microsomal cytochrome P450 activity and haem, increased the serum activity of alanine aminotransferase, and decreased the activities of glucose-6-phosphatase and aminopyrine N -demethylase (Moorthy et al ., 1989b)

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