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It has a skin barrier function and plays an important role in protecting it from external stimuli

Clinical and postmortem studies consistently demonstrate reduced BDNF expression and diminished neurogenic capacity in individuals with depression, while effective antidepressant treatments, including SSRIs, SNRIs, and electroconvulsive therapy, restore neurogenesis and promote neuronal maturation

Mitochondrial HSP60 (P1 protein) and HSP70-like protein (mortalin) are major targets for modification during S-(1,1,2,2-tetrafluoroethyl)-L-cysteine-induced toxicity