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K., Shankar, E., & Gupta, S

10.3390/jcm10020330 J Clin Med

Degradation products such as iron ions, bilirubin, and lipids are recycled by the macrophages, while residual components are secreted into the extracellular space via exocytosis, contributing to local inflammation or tissue repair (89)

Redox-active iron mediates amyloid- toxicity

In cystine-starvation-induced and xCT-inhibition-induced ferroptosis, mitochondrial rupture, mitoROS production, and mitochondrial membrane potential (MMP) loss were observed, whereas these phenomena were not observed in GPX4 inhibitor-induced ferroptosis ( 2.2 Consequence of ferroptosis Some studies suggested that ferroptosis was a form of immunogenic cell death (ICD) ( 2.3 Regulators of ferroptosis Ferroptosis regulators perform in various manners, including iron uptake, iron export, and antioxidation