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10.18632/oncotarget.13991 27 MyungP

Tolerance refers to the reduction in or loss of drug efficacy caused by long-term administration and indicated by the pharmacological changes to the right of the dose-response curve, the development and degree of which depend on the drug interactions with the opioid receptors, drug dose, and frequency of administration [15]

GSH augmentation deserves investigation as a beneficial therapeutic approach for not only PD but also numerous other CNS disorders for which GSH deficiency and GSH-related enzyme deficits have been documented (multiple sclerosis, 25,26 autism, 2729 Alzheimers disease, 30,31 schizophrenia, 32,33 and bipolar disease 34 )

Standard reconstitution uses 3mL of bacteriostatic water creating ~33.3mg/mL

Citation [1] Fu SC, Cheuk YC, Chiu WY, Yung SH, Rolf CG, Chan KM