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Trontinemab, an anti-amyloid monoclonal antibody fused to a transferrin receptor-binding shuttle module designed to enhance receptor-mediated transcytosis, is currently being evaluated in Phase I/II clinical studies, with early data indicating substantially increased brain exposure compared with conventional antibodies (Grimm et al., 2023)

These observations suggest the neuroprotective role of SIRT1 against the development and progression of PD

[3] Based on their similarity with the precursor peptide, peptidomimetics can be grouped into four classes (A D) where A features the most and D the least similarities

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To minimize the impact of nonspecific stress stimuli on the experimental animals, they should be handled for 12 min daily before the experiment