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ROS generated by the Fenton reaction tends to react with phospholipids (PL) to form hydroperoxy-phospholipids (PLOOH), which are the main elimination target of GPX4 (Wiktorowska-Owczarek et al., 2015)

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Formalin-fixed paraffin-embedded (FFPE) brain tissue from the right occipital cortex (OC) (at the level of Brodmann area 17 (BA17), area striata) of the neocortex was obtained from twelve subjects

Just think about fluid pressure in a small container being pushed, pushed, pushed until the can or the container is ready to explode, and how multiple features, multiple variables could impinge on that and create that pressure

[DOI] [PMC free article] [PubMed] [Google Scholar] 152.Joshi S, Singh AR, Durden DL