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Glucuronidation accounts for the majority of APAP metabolic pathways in healthy adults ( The precise evaluation of complex human liver metabolism and toxicity may include in silico approaches as complementary or promising alternatives to existing in vivo and in vitro approaches

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This clearly implies that, although several in vitro tests for genotoxicity assessment are available at different stages of development and acceptance, they cannot be considered to fully replace animal tests needed to evaluate the safety of substances (see Adler et al., 2011)

Brezovsky J, Babkova P, Degtjarik O, Fortova A, Gora A, Iermak I, Rezacova P, Dvorak P, Smatanova IK, Prokop Z, Chaloupkova R, Damborsky J (2016) Engineering a de novo transport tunnel

The disease may have two formsan acute one characterized by hemorrhagic diarrhea and sudden death, and a chronic one with no hemorrhagic diarrhea that causes wasting and loss of control (74)