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Food and Drug Administration has formally acknowledged their potential by including OoCs within New Approach Methodologies (NAMs) for regulatory science ( aOoC models extend these benefits by embedding patient-derived tissues, including primary cells, spheroids, or organoids, within microfluidic platforms that recapitulate organ-specific physiology

10.1016/S0891-5849(96)00375-9 Free Radic

Metabolic perturbations impair IR signaling cascades through JNK and IB kinase- (IKK) activation, leading to serine phosphorylation of IRS-1

Suppression of microRNA-342-3p increases glutamate transporters and prevents dopaminergic neuron loss through activating the Wnt signaling pathway via p21-activated kinase 1 in mice with Parkinsons disease

Human exposure to PCBs occurs mostly via ingestion of contaminated food, but also via inhalation and dermal absorption