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Degradation of the basement membrane (BM) and extracellular matrix (ECM) by matrix metalloproteinase (MMP), and the absence of smooth muscle cells and pericytes necessary for vasoconstriction significantly increase vascular permeability

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10.1111/j.1471-4159.2006.04393.x 42 HelmyA.De SimoniM.-G.GuilfoyleM

This process is governed by a specialized stem cell niche composed of diverse, spatially organized cell populations including hematopoietic stem cells (HSCs), endothelial cells (ECs), mesenchymal stromal cells (MSCs), osteolineage cells, adipocytes and immune cells 5,6

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