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Oxidative stress plays an essential and complex role throughout its occurrence and progression [2,3,4,5,6], to which reactive oxygen species (ROS) are the primary contributors

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Your genes largely determine how much melanin you produce, but sun exposure, hormones, and inflammation can also increase production and create darker spots or uneven tone

MZB have the potential to self-renew 18 and are activated more quickly than FoB 7,8 , properties consistent with a requirement for glycolytic reprogramming in activated B cells 101

The same considerations that make any hormonal intervention require clinical supervision apply here: the need for baseline laboratory assessment, individualized dosing, and ongoing monitoring to detect side effects before they become clinical problems