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Description

The diagnosis of BTBGD should be highly suspected if the patient meets any two of criteria (i) to (v) and fulfills criteria (vi) and (vii)

[26] Savage DG, Lindenbaum J, Stabler SP, et al

By blocking NNMT, 5-amino-1MQ stimulates an increase in nicotinamide adenine dinucleotide (NAD+), a cofactor that is central to cellular metabolism, thereby increasing metabolic rate and activating a gene called sirtuin-1 (SIRT1)