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EMBO J 17 : 25962606

[DOI] [PMC free article] [PubMed] [Google Scholar] 66.Aldini G., Altomare A., Baron G., Vistoli G., Carini M., Borsani L., Sergio F

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In contrast, astrocytes predominantly engage in glycolysis, producing lactate and glutathione, which are essential for supporting neuronal function and protecting against oxidative stress

225,226,227,228 Backbone modification The modification strategies used in first-generation NADs have focused on modification of the phosphate backbone, mainly using other types of groups to replace the non-bridging oxygen atoms in the phosphate backbone, such as phosphorothioate (PS), methyl phosphate, and boranophosphate