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While the short-term effects are described quite often, the long-term ones are still surrounded by uncertainties, contradictory views, and misleading information

Additional data also documented an association between BDNF and cognitive decline in PD patients, and it was hypothesized that a reduction in BDNF was associated with cognitive decline in PD patients (Wang Y

The His6-SUMO tag was cleaved by ULP1 treatment, and the tag-free protein was fractioned with Ni-NTA column and Superdex 75size exclusion column (GE Healthcare) with 25 mM HEPES (pH 8.0), 300 mM NaCl, and 1% glycerol

Keung M-H, Chan L-S, Kwok H-H, Wong RN-S, Yue PY-K

doi: 10.1080/14737175.2018.1427066 224 KobowKJeskeIHildebrandtMHaukeJHahnenEBusleiRet al