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MAT1 also interacts with p53 and DNA damage-regulated gene 1 in hepatoma cells

In addition to GSH, cysteine metabolism produces reactive sulfur species such as hydrogen polysulfides (H 2 S n ), which can act as nucleophilic and redox-active metabolites scavenging reactive oxygen species and lipid peroxyl radicals, thereby mitigating lipid peroxidation independently of the GPX4GSH axis [77,78]

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Prolonged PM2.5 exposure elevates risk of oxidative stress-driven nonalcoholic fatty liver disease by triggering increase of dyslipidemia