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98,99,100 Under oxidative stress conditions, ROS may also interfere with mtDNA replication and repair mechanism

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Our tCho result is consistent with a prior pediatric study that also found lower prefrontal tCho in sport-related concussion in comparison to controls at 3 months, despite no group differences at the acute (2472 h) timepoint 16

Further studies of natural products as immunomodulators in AL could help discover promising compounds against immune checkpoints

Oxidative stress happens when free radicals outnumber the antioxidants available to neutralize them, which can lead to cellular damage over time