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Route of administration to bypass the BBB : Intrathecal administration of drugs enables the delivery of therapeutic products to the cerebrospinal fluid, which can be distributed throughout the ventricular system and eventually enter the brain parenchyma

doi: 10.1074/jbc.M805711200

provided a comprehensive review of the pharmacological modulation of vascular aging and arterial stiffness

The safety and effectiveness of V1a antagonists in ASD have been studied in a few clinical trials [142]

Another aspect of the present invention is a carrier-linked prodrug comprising a biodegradable hydrogel of the present invention as carrier, wherein a number of permanent linkages of the backbone moieties exist with a transient prodrug linker to which a biologically active moiety is covalently attached