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300 In the parental ID8 murine ovarian cancer model harbouring a knock-out of p53 (ID8p53) and MISIIR-Tag spontaneous ovarian cancer models, CGX-1321(Wnt inhibitor) increased infiltrating CD8 + T cells in the TME and decreased tumour burden

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In addition, the recognition of commensal structures by IEC TLRs had a positive influence on paracellular permeability by promoting the normal distribution of TJ proteins required for intestinal integrity (Rakoff-Nahoum et al

Treated female mice that were given DSIP from three months of age until they died, for 5 consecutive days each month, showed a 2.6-fold decrease in tumor development and a 22.6% lower frequency of chromosomal defects in the bone marrow cells

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