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In the context of wound healing, oxidative stress can lead to the existence of a prolonged pro-inflammatory environment as well as dysregulated re-epithelialisation, as discussed in the following sections 58

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Meanwhile, it can also regulate the T cell balance in the spleen and liver, reducing the proportion of pro-inflammatory Th17 cells and increasing anti-inflammatory Tregs and IL-10 levels, thereby alleviating autoimmune liver injury

Although it is currently not clear if tamoxifen is effective in targeting other types of drug resistant cells that over-express P-gp, based on our current understanding of the mechanism of collateral sensitivity of P-gp-overexpressing cells, we speculate that tamoxifen alone or in combination with rotenone could reduce the rise of drug resistant tumor cells