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Large doses of levocarnitine may cause diarrhea

A recent study demonstrated that CBP acetylates Yes-associated protein (YAP), a key effector of the Hippo signaling pathway, at K265 in cardiomyocytes in the heart in response to MI

However, not all clinical trials have found L-carnitine supplementation to be beneficial after MI

Upon acute cold challenge, Slc25a45 -deficient mice rapidly developed hypothermia, a phenotype fully rescued by carnitine supplementation