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Overall, this work proposed a convenient, safe, and effective rectal drug delivery strategy, providing a new candidate for the prevention and treatment of radiation-induced proctitis, and also providing a reference for the design of multifunctional local delivery systems in radiation-associated tissue injury

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To date, most of the potent nAbs to SARS-CoV-2 target the RBD 57,58,59,60,61,62,63,64,65,66,67,68,69

The inhibition of methylation enzymes (DNMTs) with different molecules such as azacitidine and decitabine (drugs used in oncology), can be useful in modifying the malignant phenotype of the cells through re-expression of tumor suppressor genes [8, 47, 48]