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"Estrogen metabolism and formation of estrogen-DNA adducts in estradiol-treated MCF-10F cells"

Mitachi K, Yun HG, Gillman CD, Skorupinska-Tudek K, Swiezewska E, Clemons WM, Kurosu M

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These findings indicate a notable increase in the concentrations of these metals within the amyloid plaques of individuals diagnosed with Alzheimer's disease compared with those in adjacent healthy tissues

Moreover, in a chronic cerebral hypoperfusion mouse model, recent studies reported that dimethyl fumarate (Nrf2 activator) could inhibit NF-B-mediated inflammation and upregulate NQO1, GPX4, and HMOX1 to protect neurons from oxidative ferroptotic damage (25, 26)