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But chronic high-dose use may: Overstimulate metabolic pathways Alter methylation balance (since NNMT is tied to methyl donor cycling) Lead to unintended side effects like fatigue, irritability, or hormonal imbalance Stick to researched dosing windows (typically 1020 mg/day for short cycles in animal models) 2

There have been isolated reports of reversible hepatic injury following intravenous glutathione administration, emphasizing the need for careful monitoring, especially with repeated or high-dose therapy