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It is normal

Your body can store B12 in the liver for up to 4 years, which is why it can take years to know you have a deficiency within your diet and that your stores are depleted

In some embodiments, the invention encompasses a method of inhibiting NNMT in vitro or in vivo by contacting a cell expressing NNMT with one or more cations of the invention

The practical questions researchers ask are always the same: how much per day, and by what route

Symptoms of severe vitamin B12 deficiency can include visual disturbances, severe joint pain, paresthesia (tingling in the hands and feet), memory problems, depression, anxiety, poor muscle function, ataxia (impaired balance and coordination), changes in reflexes and even infertility