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Most symptomatic children with biotinase deficiency exhibit serum biotinase activity at 10% of normal levels or undetectable, and biotin levels in the brain and CSF are typically even lower [72]

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Among these, the complex mechanisms of phenotypic transformation of astrocytes and microglia in CVD represent an important direction for future research

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However, environmental stressors such as ionizing radiation, pollutants, heavy metals and exposure to hyperoxia greatly increase ROS production