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Furthermore, a mechanistic link between ER stress and autophagy suggests that ER stress and unfolded protein response pathways can induce the expression of autophagy-related protein by activating ER stress sensors 16

First, the voluntary nature of FAERS reporting inevitably results in reporting and notoriety bias, as well as missing information, such as comorbidity and drug combination, which have been confirmed as crucial factors in severe outcomes (Villa-Zapata et al., 2022

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