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Collagen prolyl 4-hydroxylase 1 is essential for HIF-1 stabilization and TNBC chemoresistance

In addition, NAMPT inhibition decreased the number of MDSCs and resensitized tumors to immunotherapy in mouse models in preclinical studies

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Because these are powerful bioregulators, a personalized approach is essential for achieving the best results safely

Although ApoE2 has not been extensively studied, a particular study provided evidence that ApoE2 mitigated dendritic spine loss in the hippocampus of young APP transgenic mice (Lanz et al., 2003)