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Consistent with this, baseline GSH concentrations and GST polymorphisms are associated with busulfan CL ( GSTA1 haplotype impact on CL exhibits age-dependency, reflecting the protein abundance of GSTAs in the liver increases after birth to reach adult levels during infancy ( Apart from the intra-individual variability induced by physiological maturation, busulfan-mediated GSH depletion during the treatment process may result in time-varying CL of busulfan ( Other potential covariates, such as concomitant medications, disease type, and other pathophysiological indicators, were also investigated (Supplementary Table S3)

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