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Protein, mRNA, and Immunolocalization For potential confirmation of mitochondrial biogenesis balanced with our evidence of increased mitophagy through the ketogenic diet, we analyzed the protein and mRNA of PGC-1 within the whole retina lysate, which showed no significant difference among the four groups

PMID: 31573413 Ratanapornsompong G, Sriphrapradang C

Other works found that superoxide overproduction by NADPH oxidase (NOX) has deleterious effects on PV neurons, with evidence that NOX inhibition prevents PV neuron impairment induced by either NMDAR antagonist [76] or social isolation [83]

These proteins are transferred to the nucleus, where they induce DNA fragmentation and cell death (Figure 2)