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Studies demonstrate improvements with tailored nutrition, antioxidant support, gut restoration, and correction of vitamin D, thyroid, or mitochondrial deficits

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It forces a metabolic shift from oxidative phosphorylation to glycolysis and activates established pro-reprogramming signaling pathways, such as YAP/TAZ, which exacerbate inflammatory responses and fibrosis, thereby accelerating adverse ventricular remodeling [49, 101]

[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Hansen KD