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However, more large-scale human research is still needed

American journal of physiology

In vivo, chronic intraperitoneal MG administration, particularly in the context of morphine exposure, increased CB1 receptor expression in the hippocampal CA1 region and ventral tegmental area [24]

For the other derivatives, hydrogen bonds between the carboxylate side chain of both Glu146 and Asp155 and face-to-face - stacking with Trp189 appear to be more important [78-79]