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In the skin, IGF1R signaling regulates DNA repair through downstream targets PI3K/Akt (Kemp et al., 2017a, b) or through the ATR-Chk1 kinase pathway (Strozyk and Kulms, 2013)

10.1021/ja00969a017 72 LiuJ.SunZ.YuanY.TianX.LiuX.DuanG.et al (2016)

Molecular Characteristics Complete Specifications: CAS Registry Number: 170851-70-4 Molecular Weight: 711.85 Da Molecular Formula: CHNO Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH Peptide Classification: Synthetic pentapeptide, growth hormone secretagogue Appearance: White to off-white lyophilized powder Solubility: Water, bacteriostatic water, phosphate buffered saline The peptides compact five-amino acid structure incorporates several key modifications that contribute to its unique properties

Protective effect of phenylethanoid glycosides extracted from Phlomis younghusbandii on acute high altitude pulmonary edema in rats

They also found that the expression of PRX I and PRX II was upregulated, while that of Trx1 was downregulated upon CKI administration