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Antioxidants (2021) 10(2):201

Therefore, in solution as well as in the crystalline state, Ran-GTP binding to the inner surface of importin and Kap95p induces an allosteric change on the outer surface that closes the primary FG-binding pockets, located between HEAT repeats H4H6, H9H10, and H16H17 in importin , and between H5H6 and H7H8 in Kap95p