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To overcome this challenge, efforts are being made to improve graft survival by co-transplanting with supportive cell types or neuroprotective agents [132] or employing functionalized composite scaffolds, such as those employed in mouse models of PD [133]

Amino Acids 45:133142 Aoyama K, Suh SW, Hamby AM, Liu J, Chan WY, Chen Y, Swanson RA (2006) Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse

The reduction of roGFP2(S 2 ) is therefore a good example for an enzyme using an alternative reaction pathway to overcome a kinetic challenge, and we hypothesize that other non-glutathione disulfide substrates with reactive proximal cysteinyl residues and rather negative redox potentials also require a ternary complex for their reduction

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ii) the DAPA group, which received daily oral gavage of DAPA (10 mg/kg/day