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Signal Transduction and Targeted Therapy, 8 , 372

Given dimenhydrinate and doxylamine share the same mechanism of action, it is recommended that no more than 200 mg dimenhydrinate be given to a patient concurrently taking doxylamine.[16] Multiple studies have been conducted that have failed to find any association between dimenhydrinate and congenital anomalies.[32-34] Ondansetron (Zofran) Ondansetron is a commonly used anti-emetic that works by antagonizing serotonin at the 5-HT3 receptor peripherally at the vagus nerve terminal as well as centrally at the chemoreceptor trigger zone