glutathione redox cycle and peroxide cycle. In the schematic diagram are represented the Metabolic Responses to Reductive Stress

412 Notably, the DESTINY-Breast series of studies has demonstrated significant benefits for patients with brain metastases, leading to T-DXd replacing TDM-1 and TKIs as the standard second-line treatment for advanced HER2+ breast cancer

[DOI] [PMC free article] [PubMed] [Google Scholar] 353.Tay J., Thompson C.H., Luscombe-Marsh N.D., Wycherley T.P., Noakes M., Buckley J.D., Wittert G.A., Yancy W.S., Jr., Brinkworth G.D

2008;29(2 Suppl):S2034

Statistical analysis Continuous variables were reported as mean (SD) or median, p25p75, and categoric variables as absolute frequencies and percentages

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