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Kageyama, T., Miyata, H., Seo, J., Nanmo, A

GSH deficiency as evidenced by a decrease in the GSH/GSSG ratio manifests itself largely through an increased susceptibility to oxidative stress, and the resulting damage is thought to be involved in SARS-CoV-2 infection leading to COVID-19 disease (6, 7, 39, 4353)

Glutathione is a tripeptide composed of three amino acids: L-cysteine, L-glutamic acid, and glycine

On this occasion, the authors expand our understanding of glutathione biology and identify extracellular glutathione (GSH), abundant in the tumour microenvironment, as an alternative source of essential amino acids to sustain tumour cell proliferation

Oxidative modifications to proteins, lipids, and/or DNA can alter the function of these molecules and may result in the activation of ER stress, mitochondrial dysfunction, autophagy, and apoptosis, processes that themselves also generate ROS [14]