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Tryptophan serves as a direct precursor in indole-3-acetic acid production, and its supplementation has been shown to increase yield substantially

Myhr & Brusick lymphoma cells 125-200 mg/ml c (1981) In vivo In vivo/in vitro unscheduled Wistar rat 100, 300, or 1000 Negative McManus (1987c) DNA synthesis mg/kg bw Micronucleus formation Swiss CD-1 mouse 220 mg/kg bw Negative McManus (1986) Micronucleus formation Mouse Two successive Negative d Forster et al

However, fecal microbiota transplantation (FMT) reversed diversity of gut microbiota and enhanced host defense against pneumonia (26)

Studies show it works too - a six-month trial noted higher levels of glutathione (GSH) in blood, lymphocytes, and cells, and demonstrated reduced oxidative stress as a result of supplementation

Rapid progress is being made in this field, and long-term efficacy and safety studies are underway