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For adults too, a methyl-deficient diet leads to a decrease in DNA methylation, but the changes can be reversible when methyl groups are added back to diet

DOI: 10.1016/j.cryobiol.2016.02.008

The results of this study support the efficacy of tramadol over a 6-week period for the treatment of fibromyalgia pain, assessing the cumulative probability of discontinuation of the double-blind study due to inadequate pain relief