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However, routine high-dose antioxidant therapy is not universally endorsed, as highlighted by the 2016 ASPEN-SCCM and 2019 ESPEN critical care nutrition guidelines, which caution against such interventions unless specific deficiencies are documented emphasizing the need for personalized approaches based on patient-specific needs [17,18]

Hypoxia divergently regulates production of reactive oxygen species in human pulmonary and coronary artery smooth muscle cells

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The study was a randomized, double-blinded, placebo-controlled, crossover trial---the gold standard for scientific trials