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Symptoms may include bloating, gas, diarrhea, constipation, food sensitivities, fatigue, brain fog, headaches, joint pain, mood changes, and skin conditions such as acne or eczema due to systemic inflammation

The available chemotherapy is limited, as it includes pentavalent antimonials, amphotericin B, miltefosine, and paromomycin, all of which are plagued with severe limitations such as toxicity, high production cost, decreased efficacy, difficulty in administration, and most importantly, the emergence of resistance and treatment failure [2, 4]

The expression of TNF- (Fig

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Notably, the HG-C group exhibited a significant downregulation of proteins associated with cellular metabolism, while pathways related to collagen synthesis and extracellular matrix organization were upregulated