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There is evidence that the depletion of SOD, a mitochondrial free radical scavenger, in connective tissue leads to the acceleration of skin ageing [123]

Conversely, mitigating oxidative stress specifically in HCs (via Gpx4 overexpression) reduced ERK phosphorylation in SCs, likely through EGFR signaling across the SC membrane, leading to GSDMD activation

Animals were randomized into 4 groups (16 rats each) and further allocated into 2 cohorts, one for neuronal tracing (n = 6/group) and the other for functional evaluation (n = 10/group)