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Description

Certain medications, including proton pump inhibitors (PPIs) and metformin, can interfere with B12 absorption

Diabetologia 58 , 666677 (2015)

Sodium depletion has also been associated with cramps

Evidence from North America, Europe, Asia, Africa, and Latin America consistently highlights the need for routine B12 monitoring and supplementation, especially in elderly patients and those on high-dose or long-term therapy