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39 The outcome of these studies reinforces the notion that the intestinal epithelium is essential for separating luminal antigens from mucosal immune components, and that its disruption by altered proliferation/apoptosis ratio can result in immune activation and inflammation (Figure 1)

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For example, the body produces methylmalonic acid (MMA) in the blood when it's either not getting enough B12 or not using B12 properly

Im looking forward very much to jumping into that and dispelling some confusion