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Six variants were observed to be damaged by using the SIFT tool and were further subjected to cross check by using five different tools (WHESS.db submodule PolyPhen-2 server, Mutation testers, SNPs&Go, SNAP2 and Provean tools)

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Taking enzyme-responsive nanomaterials as an example, there are notable physiological and tumor microenvironment differences between animal models and human models in preclinical biosafety evaluations, complicating their clinical translation (Cao et al., 2019)